PUBLICATIONS

2026

Vardazaryan N, Adunts L, Bazukyan I, Zakharyan M, Liu H, Melkonian C, Nersisyan L. A network-based meta-analysis of the honeybee gut microbiome: geographic, seasonal, and pesticide-associated shifts. Sci Rep. 2026
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Konecny T, Zadirako N, Grigoryan A, Tamazyan M, Mnatsakanyan S, Stepanyan L, Loeffler-Wirth H, Bourdelais S, Mednick G, Delepine C, Chand D, Binder H Transcriptomic profiling identifies immunotherapy-responsive phenotypes in microsatellite-stable metastatic colorectal cancer. Oncogene, 2026.
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Konecny T, Binder H, Hampel U, Hansmann F, Pfannkuche H, Schneider MR. Spotting a unicorn: spatial transcriptome analysis of the eyelid reveals gene regulatory networks enriched in Moll glands. Briefings in Bioinformatics, 2026.
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Baloyan A, Konecny T, Hovhannisyan E, Zadirako N, Nikoghosyan M, Binder H. A topological map of the genetic components of grapevine—Admixture meets SOMmelier machine learning. PLOS Computational Biology, 2026.
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Nikoghosyan M, Hovhannisyan E, Zadirako N, Duan S, Asatryan A, Arakelyan A, Margaryan K, Baloyan A, Konecny T, Binder H. Population structure of wild and cultivated grapevines in Armenia. BMC Plant Biology, 2026.
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Liu H, Huch S, Hull R, Garcia FR, Nersisyan L, Yin X, Chen WH, Du J, Pelechano V. A streamlined, nanopore-compatible 5PSeq protocol for rapid phenotypic antimicrobial sensitivity testing. Cell Rep Methods. 2026.
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Gouka L, Serra i Melendez C, Vardazaryan N. et al. Genomic insights into adaptative traits of phyllosphere yeasts. Environmental Microbiome, 2026

2025

Borisov N, Ilnytsky Y, Byeon B, Kovalchuk O, Kovalchuk I. Multi-omics data integration for topology-based pathway activation assessment and personalized drug ranking. Molecular Omics, 2025
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Binder H, Hampel U, Loeffler-Wirth H, Hansmann F, Pfannkuche H, Schmidt M, Schneider MR. Spatial transcriptome analysis of the human eyelid depicts meibomian gland cell differentiation: A pilot study. Physiological Reports, 2025
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Schmidt M, Binder H, Schneider MR. The metabolic underpinnings of sebaceous lipogenesis. Communications Biology, 2025
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Konecny T, Asatryan A, Binder H. Responding to Stress: Diversity and Resilience of Grapevine in a Changing Climate Under the Perspective of Omics Research. International Journal of Molecular Sciences, 2025
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Hakobyan S, Schmidt M, Binder H, Arakelyan A. Topology-aware pathway analysis of spatial transcriptomics. PeerJ, 2025
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Hakobyan M, Binder H, Arakelyan A. Telomere Maintenance Pathways in Lower-Grade Gliomas: Insights from Genetic Subtypes and Telomere Length Dynamics. International Journal of Molecular Sciences, 2025
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Jalatyan T, Aznauryan E, Hasan R, Vardanyan V, Nersisyan S, Thompson DB, Davidsohn N, Thomas S, van Haren S, Tam J, Milanova D, Church GM, Nersisyan L. hafoe: an interactive tool for the analysis of chimeric AAV libraries after random mutagenesis. Gene Therapy, 2025
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Zhang Y, Nersisyan L, Fürst E, Alexopoulos I, Santolaria C, Huch S, Bassot C, Garre E, Sunnerhagen P, Piazza I, Pelechano V. Ribosomes modulate transcriptome abundance via generalized frameshift and out-of-frame mRNA decay. Molecular Cell, 2025
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Arakelyan A, Sirunyan T, Khachatryan G, Hakobyan S, Minasyan A, Nikoghosyan M, Hakobyan M, Chavushyan A, Martirosyan G, Hakobyan Y, Binder H. Assigning Transcriptomic Subtypes to Chronic Lymphocytic Leukemia Samples Using Nanopore RNA-Sequencing and Self-Organizing Maps. Cancers (Basel), 2025
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2024

Ghukasyan L, Khachatryan G, Sirunyan T, Minasyan A, Hakobyan S, Chavushyan A, Hayrapetyan V, Ghazaryan H, Martirosyan G, Mkrtchyan G, Vardanyan V, Mukuchyan V, Davidyants A, Zakharyan R, Arakelyan A. Genewise detection of variants in MEFV gene using nanopore sequencing. Frontiers in Genetics, 2024
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Wahis J, Akkaya C, Kirunda AM, Mak A, Zeise K, Verhaert J, Gasparyan H, Hovhannisyan S, Holt MG. The astrocyte α1A-adrenoreceptor is a key component of the neuromodulatory system in mouse visual cortex. Glia, 2024
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Martirosyan A, Ansari R, Pestana F, Hebestreit K, Gasparyan H, Aleksanyan R, Hnatova S, Poovathingal S, Marneffe C, Thal DR, Kottick A, Hanson-Smith VJ, Guelfi S, Plumbly W, Belgard TG, Metzakopian E, Holt MG. Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution․ Molecular Neurodegeneration, 2024
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Bielefeld P, Martirosyan A, Martín-Suárez S, Apresyan A, Meerhoff GF, Pestana F, Poovathingal S, Reijner N, Koning W, Clement RA, Van der Veen I, Toledo EM, Polzer O, Durá I, Hovhannisyan S, Nilges BS, Bogdoll A, Kashikar ND, Lucassen PJ, Belgard TG, Encinas JM, Holt MG, Fitzsimons CP. Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice. Nature Communications, 2024
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Turnbull K, Paternoga H, von der Weth E, Egorov AA, Pochopien AA, Zhang Y, et al. The ABCF ATPase New1 resolves translation termination defects associated with specific tRNAArg and tRNALys isoacceptors in the P site. Nucleic Acids Research, 2024
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Davitavyan S, Martirosyan G, Mkrtchyan G, Chavushyan A, Melkonyan A, Ghazaryan H, Binder H, Arakelyan A: Integrated analysis of -omic landscapes in breast cancer subtypes. F1000Research, 2024
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Hakobyan A, Meyenberg M, Vardazaryan N, Hancock J, Vulliard L, Loizou JI, et al. Pan-cancer analysis of the interplay between mutational signatures and cellular signaling. iScience, 2024
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Hakobyan M, Binder H, Arakelyan A. Pan-canceranalysis of telomere maintenance mechanisms. Journal of Biological Chemistry, 2024
Schmidt M․, Avagyan S․, Reiche K., Binder B., Loeffler-Wirth H. (2024). A Spatial Transcriptomics Browser for Discovering Gene Expression Landscapes across Microscopic Tissue Sections. Current Issues in Molecular Biology, 2024
Arakelyan A, Avagyan S, Kurnosov A, Mkrtchyan T, Mkrtchyan G, Zakharyan R, R Mayilyan K, Binder H. Temporal changes of gene expression in health, schizophrenia, bipolar disorder, and major depressive disorder. Schizophrenia, 2024

2023

Staroverov V, Nersisyan S, Galatenko A, Alekseev D, Lukashevich S, Polyakov F, Anisimov N, Tonevitsky A. Development of a novel mathematical model that explains SARS-CoV-2 infection dynamics in Caco-2 cells. PeerJ, 2023
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Dong Y, Duan S, Xia Q, Liang Z, Dong X, Margaryan K, Musayev M, Goryslavets S, Zdunić G, Bert PF, Lacombe T, Maul E, Nick P, Bitskinashvili K, Bisztray GD, Drori E, De Lorenzis G, Cunha J, Popescu CF, Arroyo-Garcia R, Arnold C, Ergül A, Zhu Y, Ma C, Wang S, Liu S, Tang L, Wang C, Li D, Pan Y, Li J, Yang L, Li X, Xiang G, Yang Z, Chen B, Dai Z, Wang Y, Arakelyan A, et al. Dual domestications and origin of traits in grapevine evolution. Science, 2023
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Everest-Dass A, Nersisyan S, Maar H, Novosad V, Schröder-Schwarz J, Freytag V, et al. Spontaneous metastasis xenograft models link CD44 isoform 4 to angiogenesis, hypoxia, EMT and mitochondria-related pathways in colorectal cancer. Molecular Oncology, 2024
Hakobyan S, Stepanyan A, Nersisyan L, Binder H, Arakelyan A. PSF toolkit: an R package for pathway curation and topology-aware analysis. Frontiers in Genetics, 2023
Avagyan S, Binder H. Subtyping or not subtyping—Quo vadis for precision medicine of colorectal cancer. Translational Cancer Research, 2023
Huch S, Nersisyan L, Ropat M, Barrett D, Wu M, Wang J, et al. Atlas of mRNA translation and decay for bacteria. Nature Microbiology, 2023
Zhiyanov A, Engibaryan N, Nersisyan S, Shkurnikov M, Tonevitsky A. Differential co-expression network analysis with DCoNA reveals isomiR targeting aberrations in prostate cancer. Bioinformatics, 2023
Magaryan K, Nikogհosyan M, Baloyan A, Gasoyan H, Hovhannisyan E, Galstyan L, ... Binder H, Machine learned-based visualization of the diversity of grapevine genomes worldwide and in Armenia using SOMmelier. BIO Web Conferences, 2023
Shkurnikov M, Nersisyan S, Averinskaya D, Chekova M, Polyakov F, Titov A, et al. HLA-A*01:01 allele diminishing in COVID-19 patients population associated with non-structural epitope abundance in CD8+ T-cell repertoire. PeerJ, 2023

2022

Avetyan D, Hakobyan S, Nikoghosyan M, Ghukasyan L, Khachatryan G, Sirunyan T, Muradyan N, Zakharyan R, Chavushyan A, Hayrapetyan V, Hovhannisyan A, Mohamed Bakhash SA, Jerome KR, Roychoudhury P, Greninger AL, Niazyan L, Davidyants M, Melik-Andreasyan G, Sargsyan S, Nersisyan L, Arakelyan A. Molecular Analysis of SARS-CoV-2 Lineages in Armenia. Viruses, 2022
Nersisyan S, Gorbonos A, Makhonin A, Zhiyanov A, Shkurnikov M, Tonevitsky A. isomiRTar: a comprehensive portal of pan-cancer 50-isomiR targeting. PeerJ, 2022
Loeffler-Wirth H, Rade M, Arakelyan A, Kreuz M, Loeffler M, Koehl U, Reiche K, Binder H. Transcriptional states of CAR-T infusion relate to neurotoxicity – lessons from high-resolution single-cell SOM expression portraying. Frontiers in Immunology, 2022
Binder H, Schmidt M, Hopp L, Davitavyan S, Arakelyan A, Loeffler-Wirth H. Integrated Multi-Omics Maps of Lower-Grade Gliomas. Cancers, 2022
Nersisyan S, Zhiyanov A, Zakharova M, Ishina I, Kurbatskaia I, Mamedov A, et al. Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules. PeerJ, 2022
Nikoghosyan M, Loeffler-Wirth H, Davidavyan S, Binder H, Arakelyan A. Projection of High-Dimensional Genome-Wide Expression on SOM Transcriptome Landscapes. BioMedInformatics, 2022
Loeffler-Wirth H, Hopp L, Schmidt M, Zakharyan R, Arakelyan A, Binder H. The Transcriptome and Methylome of the Developing and Aging Brain and Their Relations to Gliomas and Psychological Disorders. Cells, 2022
Goukassian D, Arakelyan A, Brojakowska A, Bisserier M, Hakobyan S, Hadri L, et al. Space flight associated changes in astronauts’ plasma-derived small extracellular vesicle microRNA: Biomarker identification. Clinical and Translational Medicine, 2022

2021

Schmidt M, Arshad M, Bernhart SH, Hakobyan S, Arakelyan A, Loeffler-Wirth H, Binder H. The Evolving Faces of the SARS-CoV-2 Genome. Viruses, 2021
Willscher E, Hopp L, Kreuz M, Schmidt M, Hakobyan S, Arakelyan A... Binder H. High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas. Cancers, 2021
Al-Sanea MM, Chilingaryan G, Abelyan N, Sargsyan A, Hovhannisyan S, Gasparyan H, et al. Identification of Novel Potential VEGFR-2 Inhibitors Using a Combination of Computational Methods for Drug Discovery. Life, 2021